What is Upstream Bio, Inc.'s EBITDA?

Upstream Bio, Inc. (UPB) reported EBITDA of -$43.57M in Q1 2026.

How has Upstream Bio, Inc.'s EBITDA changed year-over-year?

Upstream Bio, Inc.'s EBITDA decreased by 36.3% year-over-year, from -$31.97M to -$43.57M.

What does EBITDA mean?

Earnings before interest, taxes, depreciation, and amortization — EBIT plus the D&A add-back from the cash-flow statement (EBITDA = EBIT + D&A). A proxy for cash earnings that strips out financing, tax, and non-cash charges.

Upstream Bio, Inc. UPB EBITDA

EBITDA at other companies

Aclaris TherapeuticsACRS

-$22.09M-23.0%

Shattuck Labs, Inc.STTK

-$14.65M-8.9%

SavaraSVRA

-$38.97M-37.2%

AnaptysBio, Inc.ANAB

-$34.51M-26.0%

AmgenAMGN

——

Regeneron PharmaceuticalsREGN

——

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

See full

Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

See full

Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

−$43.6Mebit+

$49.0KDepreciation Depletion & Amortization

=-$43.57M

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s EBITDA?: Upstream Bio, Inc. (UPB) reported EBITDA of -$43.57M in Q1 2026.
How has Upstream Bio, Inc.'s EBITDA changed year-over-year?: Upstream Bio, Inc.'s EBITDA decreased by 36.3% year-over-year, from -$31.97M to -$43.57M.
What does EBITDA mean?: Earnings before interest, taxes, depreciation, and amortization — EBIT plus the D&A add-back from the cash-flow statement (EBITDA = EBIT + D&A). A proxy for cash earnings that strips out financing, tax, and non-cash charges.