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Other financials

Income statement

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Revenue$773.0K-17.5%
Operating income-$42.4M+4.5%
Net income-$39.7M+0.7%
EPS (diluted)-$0.73+1.4%

Balance sheet

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Cash & equivalents$79.4M+74.7%
Total debt$954.0K-38.9%
Total equity$271.0M-33.7%
Total assets$281.2M-33.1%

Cash flow

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Operating cash flow-$35.6M+9.2%
CapEx$54.0K-70.8%
Free cash flow-$30.7M-55.0%

Valuation

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Market cap$394.54M-54.7%
Enterprise value$316.1M-61.6%
P/S124.9×-195×

Profitability

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Operating margin-5,382.6%+1,393pp
Net margin-4,955.7%+2,041pp

Returns & leverage

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Return on equity-46%
Debt / equity0.0×
Current ratio28×-10.3×

Where this comes from

Reported directly by Upstream Bio, Inc. in its filing.

Tagged under the XBRL concept us-gaap:GeneralAndAdministrativeExpense.

The source filing: Upstream Bio, Inc.’s 10-Q, filed August 11, 2026.

Filed
Aug 11, 2026, 7:10 AM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0001193125-26-343417
Line itemThree Months Ended June 30, 2026Three Months Ended June 30, 2025Six Months Ended June 30, 2026Six Months Ended June 30, 2025
Collaboration revenue$773$937$1,807$1,503
Operating expenses:
Research and development36,08937,86572,65463,662
General and administrative7,0527,41915,13614,201
Total operating expenses43,14145,28487,79077,863
Loss from operations(42,368)(44,347)(85,983)(76,360)
Other income (expense):
Interest income2,6594,4315,7139,174

Item 1. Financial Statements.

FAQ

What is Upstream Bio, Inc.'s G&A?
Upstream Bio, Inc. (UPB) reported G&A of $7.05M in Q2 2026.
How has Upstream Bio, Inc.'s G&A changed year-over-year?
Upstream Bio, Inc.'s G&A decreased by 4.9% year-over-year, from $7.42M to $7.05M.
What does G&A mean?
Overhead costs not directly tied to production or sales — corporate management, legal, accounting, office rent, insurance, and other administrative functions.

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