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Upstream Bio, Inc. UPB Net Change in Cash

Net Change in Cash at other companies

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Other financials

Income statement

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Revenue$773.0K-17.5%
Operating income-$42.4M+4.5%
Net income-$39.7M+0.7%
EPS (diluted)-$0.73+1.4%

Balance sheet

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Cash & equivalents$79.4M+74.7%
Total debt$954.0K-38.9%
Total equity$271.0M-33.7%
Total assets$281.2M-33.1%

Cash flow

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Operating cash flow-$35.6M+9.2%
CapEx$54.0K-70.8%
Free cash flow-$30.7M-55.0%

Valuation

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Market cap$394.54M-54.7%
Enterprise value$316.1M-61.6%
P/S124.9×-195×

Profitability

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Operating margin-5,382.6%+1,393pp
Net margin-4,955.7%+2,041pp

Returns & leverage

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Return on equity-46%
Debt / equity0.0×
Current ratio28×-10.3×

Where this comes from

Reported directly by Upstream Bio, Inc. in its filing.

Tagged under the XBRL concept us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect.

The source filing: Upstream Bio, Inc.’s 10-Q, filed August 11, 2026.

Filed
Aug 11, 2026, 7:10 AM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0001193125-26-343417
Line itemSix Months Ended June 30, 2026Six Months Ended June 30, 2025
Proceeds from issuance of common stock under stock plans1,048612
Payments of initial public offering costs(34)
Net cash provided by financing activities3,131578
Net decrease in cash, cash equivalents and restricted cash(22,181)(280,434)
Cash, cash equivalents and restricted cash at beginning of period101,772326,086
Cash, cash equivalents and restricted cash at end of period$79,591$45,652
Cash, cash equivalents and restricted cash at end of period:
Cash and cash equivalents$79,397$45,458

Item 1. Financial Statements.

FAQ

What is Upstream Bio, Inc.'s net change in cash?
Upstream Bio, Inc. (UPB) reported net change in cash of -$17.33M in Q2 2026.
How has Upstream Bio, Inc.'s net change in cash changed year-over-year?
Upstream Bio, Inc.'s net change in cash increased by 33.0% year-over-year, from -$25.85M to -$17.33M.
What does net change in cash mean?
Total increase or decrease in cash during the period — the sum of operating, investing, financing cash flows plus FX effects.

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