What is Upstream Bio, Inc.'s net income?

Upstream Bio, Inc. (UPB) reported net income of -$40.59M in Q1 2026.

How has Upstream Bio, Inc.'s net income changed year-over-year?

Upstream Bio, Inc.'s net income decreased by 48.8% year-over-year, from -$27.27M to -$40.59M.

What is the long-term trend for Upstream Bio, Inc.'s net income?

Over 2 years (2023 to 2025), Upstream Bio, Inc.'s net income has grown at a 164.3% compound annual growth rate (CAGR), from -$20.54M to -$143.44M.

What does net income mean?

Net income as the starting point for the indirect method operating cash flow reconciliation.

Upstream Bio, Inc. UPB Net Income

Net Income at other companies

AmgenAMGN

$1.82B+5.1%

Regeneron PharmaceuticalsREGN

$727.2M-10.1%

Aclaris TherapeuticsACRS

-$19.82M-31.4%

Shattuck Labs, Inc.STTK

-$14.77M-7.8%

SavaraSVRA

-$37.28M-40.0%

AnaptysBio, Inc.ANAB

-$52.88M-34.5%

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

See full

Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Reported directly by Upstream Bio, Inc. in its filing.

Tagged under the XBRL concept us-gaap:ProfitLoss.

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s net income?: Upstream Bio, Inc. (UPB) reported net income of -$40.59M in Q1 2026.
How has Upstream Bio, Inc.'s net income changed year-over-year?: Upstream Bio, Inc.'s net income decreased by 48.8% year-over-year, from -$27.27M to -$40.59M.
What is the long-term trend for Upstream Bio, Inc.'s net income?: Over 2 years (2023 to 2025), Upstream Bio, Inc.'s net income has grown at a 164.3% compound annual growth rate (CAGR), from -$20.54M to -$143.44M.
What does net income mean?: Net income as the starting point for the indirect method operating cash flow reconciliation.