How has Ionis Pharmaceuticals's long-term marketable securities changed year-over-year?

Ionis Pharmaceuticals's long-term marketable securities decreased by 7.4% year-over-year, from $681.35M to $630.67M.

What is the long-term trend for Ionis Pharmaceuticals's long-term marketable securities?

Over 4 years (2021 to 2025), Ionis Pharmaceuticals's long-term marketable securities has grown at a 5.1% compound annual growth rate (CAGR), from $635.12M to $773.71M.

Ionis Pharmaceuticals IONS Long-term marketable securities

Long-term marketable securities at other companies

Bristol-Myers SquibbBMY

$366M+6.4%

PfizerPFE

——

Neurocrine BiosciencesNBIX

——

Royalty PharmaRPRX

——

Other financials

Income statement

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Revenue$246.1M+87.0%

Gross profit$243.1M+86.8%

Operating income-$117.4M+20.0%

Net income-$92.5M+37.0%

EPS (diluted)-$0.56+39.8%

Balance sheet

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Cash & equivalents$173.4M-34.4%

Total debt$691.7M+334%

Total equity$491.4M+3.3%

Total assets$3.4B+22.6%

Cash flow

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Operating cash flow-$792.8M-426%

CapEx$21.8M+73.0%

Free cash flow-$814.6M-399%

Valuation

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Market cap$12.25B+159%

Enterprise value$12.77B+175%

P/S11.6×+5.0×

Profitability

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Gross margin98.4%-0.2pp

Operating margin-33.3%-11.0pp

Net margin-30.9%-10.5pp

FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-67.6%-20.3pp

Debt / equity1.4×+1.1×

Current ratio4.1×-5.6×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:AvailableForSaleSecuritiesDebtSecuritiesNoncurrent.

The official record: Ionis Pharmaceuticals’s 10-Q, filed April 29, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Ionis Pharmaceuticals's long-term marketable securities?: Ionis Pharmaceuticals (IONS) reported long-term marketable securities of $630.67M in Q1 2026.
How has Ionis Pharmaceuticals's long-term marketable securities changed year-over-year?: Ionis Pharmaceuticals's long-term marketable securities decreased by 7.4% year-over-year, from $681.35M to $630.67M.
What is the long-term trend for Ionis Pharmaceuticals's long-term marketable securities?: Over 4 years (2021 to 2025), Ionis Pharmaceuticals's long-term marketable securities has grown at a 5.1% compound annual growth rate (CAGR), from $635.12M to $773.71M.