What is Ionis Pharmaceuticals's gross unrealized gains?

Ionis Pharmaceuticals (IONS) reported gross unrealized gains of $1.11M in Q1 2026.

How has Ionis Pharmaceuticals's gross unrealized gains changed year-over-year?

Ionis Pharmaceuticals's gross unrealized gains decreased by 55.8% year-over-year, from $2.5M to $1.11M.

What is the long-term trend for Ionis Pharmaceuticals's gross unrealized gains?

Over 4 years (2021 to 2025), Ionis Pharmaceuticals's gross unrealized gains has grown at a 35.2% compound annual growth rate (CAGR), from $1.26M to $4.22M.

Ionis Pharmaceuticals IONS Gross Unrealized Gains

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Other financials

Income statement

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Revenue$246.1M+87.0%

Gross profit$243.1M+86.8%

Operating income-$117.4M+20.0%

Net income-$92.5M+37.0%

EPS (diluted)-$0.56+39.8%

Balance sheet

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Cash & equivalents$173.4M-34.4%

Total debt$691.7M+334%

Total equity$491.4M+3.3%

Total assets$3.4B+22.6%

Cash flow

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Operating cash flow-$792.8M-426%

CapEx$21.8M+73.0%

Free cash flow-$814.6M-399%

Valuation

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Market cap$12.25B+159%

Enterprise value$12.77B+175%

P/S11.6×+5.0×

Profitability

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Gross margin98.4%-0.2pp

Operating margin-33.3%-11.0pp

Net margin-30.9%-10.5pp

FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-67.6%-20.3pp

Debt / equity1.4×+1.1×

Current ratio4.1×-5.6×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax.

The official record: Ionis Pharmaceuticals’s 10-Q, filed April 29, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Ionis Pharmaceuticals's gross unrealized gains?: Ionis Pharmaceuticals (IONS) reported gross unrealized gains of $1.11M in Q1 2026.
How has Ionis Pharmaceuticals's gross unrealized gains changed year-over-year?: Ionis Pharmaceuticals's gross unrealized gains decreased by 55.8% year-over-year, from $2.5M to $1.11M.
What is the long-term trend for Ionis Pharmaceuticals's gross unrealized gains?: Over 4 years (2021 to 2025), Ionis Pharmaceuticals's gross unrealized gains has grown at a 35.2% compound annual growth rate (CAGR), from $1.26M to $4.22M.