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Ionis Pharmaceuticals IONS Effect of exchange rate changes on cash and cash equivalents

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Other financials

Income statement

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Revenue$246.1M+87.0%
Gross profit$243.1M+86.8%
Operating income-$117.4M+20.0%
Net income-$92.5M+37.0%
EPS (diluted)-$0.56+39.8%

Balance sheet

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Cash & equivalents$173.4M-34.4%
Total debt$691.7M+334%
Total equity$491.4M+3.3%
Total assets$3.4B+22.6%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$21.8M+73.0%
Free cash flow-$814.6M-399%

Valuation

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Market cap$12.25B+159%
Enterprise value$12.77B+175%
P/S11.6×+5.0×

Profitability

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Gross margin98.4%-0.2pp
Operating margin-33.3%-11.0pp
Net margin-30.9%-10.5pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-67.6%-20.3pp
Debt / equity1.4×+1.1×
Current ratio4.1×-5.6×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsDisposalGroupIncludingDiscontinuedOperations.

The official record: Ionis Pharmaceuticals’s 10-K, filed February 26, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Ionis Pharmaceuticals's effect of exchange rate changes on cash and cash equivalents?
Ionis Pharmaceuticals (IONS) reported effect of exchange rate changes on cash and cash equivalents of $175.5K in Q4 2025.
How has Ionis Pharmaceuticals's effect of exchange rate changes on cash and cash equivalents changed year-over-year?
Ionis Pharmaceuticals's effect of exchange rate changes on cash and cash equivalents increased by 357.1% year-over-year, from -$68.25K to $175.5K.
What is the long-term trend for Ionis Pharmaceuticals's effect of exchange rate changes on cash and cash equivalents?
Over 2 years (2023 to 2025), Ionis Pharmaceuticals's effect of exchange rate changes on cash and cash equivalents has grown at a 41.2% compound annual growth rate (CAGR), from $352K to $702K.
What does effect of exchange rate changes on cash and cash equivalents mean?
The change in cash value caused by shifting foreign currency exchange rates.
How do you interpret effect of exchange rate changes on cash and cash equivalents?
Reflects external macroeconomic volatility rather than operational performance, though large values indicate significant international exposure.
How does effect of exchange rate changes on cash and cash equivalents compare across companies?
Standard accounting adjustment for companies with global operations or foreign currency holdings.