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Ionis Pharmaceuticals IONS Effect of cross-border tax laws

Effect of cross-border tax laws at other companies

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Jazz PharmaceuticalsJAZZ
-4.7%—

Other financials

Income statement

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Revenue$246.1M+87.0%
Gross profit$243.1M+86.8%
Operating income-$117.4M+20.0%
Net income-$92.5M+37.0%
EPS (diluted)-$0.56+39.8%

Balance sheet

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Cash & equivalents$173.4M-34.4%
Total debt$691.7M+334%
Total equity$491.4M+3.3%
Total assets$3.4B+22.6%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$21.8M+73.0%
Free cash flow-$814.6M-399%

Valuation

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Market cap$12.25B+159%
Enterprise value$12.77B+175%
P/S11.6×+5.0×

Profitability

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Gross margin98.4%-0.2pp
Operating margin-33.3%-11.0pp
Net margin-30.9%-10.5pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-67.6%-20.3pp
Debt / equity1.4×+1.1×
Current ratio4.1×-5.6×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:EffectiveIncomeTaxRateReconciliationCrossBorderTaxEffectPercent.

The official record: Ionis Pharmaceuticals’s 10-K, filed February 26, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Ionis Pharmaceuticals's effect of cross-border tax laws?
Ionis Pharmaceuticals (IONS) reported effect of cross-border tax laws of -0.1% in Q4 2025.
What does effect of cross-border tax laws mean?
The percentage impact of cross-border tax effects on the effective tax rate.
How do you interpret effect of cross-border tax laws?
A high impact suggests significant tax volatility related to international operations.
How does effect of cross-border tax laws compare across companies?
Standard disclosure in effective tax rate reconciliation tables.