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Ionis Pharmaceuticals IONS Effective Income Tax Rate Reconciliation Orphan Drug Tax Credits Percent

Effective Income Tax Rate Reconciliation Orphan Drug Tax Credits Percent at other companies

Xylem logo
XylemXYL
1.3%-1.3pp
NiSource logo
NiSourceNI
-2.7%+10.8pp
Baxter International logo
Baxter InternationalBAX
-4.8%
PayPal Holdings, Inc. logo
PayPal Holdings, Inc.PYPL
-0.6%-1.3pp
Knight-Swift Transportation Holdings Inc. logo
Knight-Swift Transportation Holdings Inc.KNX
2.6%
Caterpillar logo
CaterpillarCAT
1.8%+0.5pp

Other financials

Income statement

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Revenue$246.1M+87.0%
Gross profit$243.1M+86.8%
Operating income-$117.4M+20.0%
Net income-$92.5M+37.0%
EPS (diluted)-$0.56+39.8%

Balance sheet

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Cash & equivalents$173.4M-34.4%
Total debt$691.7M+334%
Total equity$491.4M+3.3%
Total assets$3.4B+22.6%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$21.8M+73.0%
Free cash flow-$814.6M-399%

Valuation

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Market cap$12.25B+159%
Enterprise value$12.77B+175%
P/S11.6×+5.0×

Profitability

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Gross margin98.4%-0.2pp
Operating margin-33.3%-11.0pp
Net margin-30.9%-10.5pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-67.6%-20.3pp
Debt / equity1.4×+1.1×
Current ratio4.1×-5.6×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept ions:EffectiveIncomeTaxRateReconciliationOrphanDrugTaxCreditsPercent.

The official record: Ionis Pharmaceuticals’s 10-K, filed February 26, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Ionis Pharmaceuticals's effective income tax rate reconciliation orphan drug tax credits percent?
Ionis Pharmaceuticals (IONS) reported effective income tax rate reconciliation orphan drug tax credits percent of -8% in Q4 2025.
What does effective income tax rate reconciliation orphan drug tax credits percent mean?
The percentage point reduction in the effective tax rate due to orphan drug tax credits.
How do you interpret effective income tax rate reconciliation orphan drug tax credits percent?
An increase indicates that orphan drug incentives are playing a larger role in optimizing the company's tax position.
How does effective income tax rate reconciliation orphan drug tax credits percent compare across companies?
Used by investors to gauge the tax-related benefits of a company's rare disease portfolio.