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Ionis Pharmaceuticals IONS Valuation Allowances And Reserves Period Increase Decrease

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Other financials

Income statement

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Revenue$246.1M+87.0%
Gross profit$243.1M+86.8%
Operating income-$117.4M+20.0%
Net income-$92.5M+37.0%
EPS (diluted)-$0.56+39.8%

Balance sheet

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Cash & equivalents$173.4M-34.4%
Total debt$691.7M+334%
Total equity$491.4M+3.3%
Total assets$3.4B+22.6%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$21.8M+73.0%
Free cash flow-$814.6M-399%

Valuation

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Market cap$12.25B+159%
Enterprise value$12.77B+175%
P/S11.6×+5.0×

Profitability

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Gross margin98.4%-0.2pp
Operating margin-33.3%-11.0pp
Net margin-30.9%-10.5pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-67.6%-20.3pp
Debt / equity1.4×+1.1×
Current ratio4.1×-5.6×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:ValuationAllowancesAndReservesPeriodIncreaseDecrease.

The official record: Ionis Pharmaceuticals’s 10-K, filed February 26, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Ionis Pharmaceuticals's valuation allowances and reserves period increase decrease?
Ionis Pharmaceuticals (IONS) reported valuation allowances and reserves period increase decrease of $26.75M in Q4 2025.
What does valuation allowances and reserves period increase decrease mean?
The change in the reserve set aside for tax assets that may not be usable.
How do you interpret valuation allowances and reserves period increase decrease?
A decrease in the allowance often signals improved future profitability expectations, while an increase suggests uncertainty regarding tax asset realization.
How does valuation allowances and reserves period increase decrease compare across companies?
High volatility is common in pre-revenue or early-stage commercial companies.