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Septerna, Inc. SEPN Q2 2026 earnings

Reported August 10, 2026 · After market close

Revenue$26.7MBeat by $7.5M
EPS-$0.29Beat by $0.14
Revenue estimate$19.2M
EPS estimate-$0.43
We are advancing our Phase 1 study of SEP-479 and are very pleased with the observed clinical half-life, which is at the longer end of our preclinical estimates. This finding reinforces our confidence in the potential of SEP-479 as a differentiated, once-daily oral treatment for hypoparathyroidism, and we look forward to presenting SAD/MAD data in the first quarter of 2027. We are also advancing our broader portfolio by evaluating the next phase of development for SEP-631 in mast cell-driven diseases and progressing our TSHR program toward development candidate selection.
Jeffrey Finer

Next report

Nov 9, 2026 (in 2 months)
Revenue estimate$20.8M
EPS estimate-$0.42

Financials

Q2 2026

Income statement

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Revenue$26.7M+22,376%
Operating income-$16.8M+41.9%
Net income-$13.0M+47.5%
EPS (diluted)-$0.29+48.2%

Balance sheet

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Cash & equivalents$84.7M-55.3%
Total debt$22.5M-8.2%
Total equity$386.7M+2.4%
Total assets$566.7M+36.5%

Cash flow

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Operating cash flow-$22.2M-9.3%
Free cash flow-$22.2M-9.0%

Valuation & ratios

Valuation

as of 08/27/26
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Market cap$1.88B+234%
Enterprise value$1.82B+356%
P/S19×-756×

Profitability

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Operating margin-44%-22.0pp
Net margin-24.5%-12.2pp

Returns & leverage

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Return on equity-6.3%
Debt / equity0.1×0.0×
Current ratio-17.1×

FAQ

When did Septerna, Inc. report Q2 2026 earnings?
Septerna, Inc. (SEPN) reported Q2 2026 earnings on August 10, 2026 after market close.
What were Septerna, Inc.'s Q2 2026 revenue and EPS?
Septerna, Inc. reported revenue of $26.7M and eps of $-0.29 for Q2 2026.
Did Septerna, Inc. beat estimates in Q2 2026?
Revenue beat the consensus estimate of $19.2M by $7.5M. EPS beat the consensus estimate of $-0.43 by $0.14.
How did Septerna, Inc.'s Q2 2026 results compare year-over-year?
Compared to the same quarter a year prior, revenue grew 22375.6% from $119.0K a year earlier and eps grew 48.2% from $-0.56.
Where can I find Septerna, Inc.'s Q2 2026 SEC filings?
You can read the 8-K earnings release (0001193125-26-342328) and the 10-Q periodic report (0001193125-26-342353) directly on SEC EDGAR. The filing index links above go to sec.gov.