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Septerna, Inc. SEPN Q3 2025 earnings

Reported November 10, 2025 · Before market open

Revenue$21.5MBeat by $4.2M
EPS-$0.09Miss by $0.28
Revenue estimate$17.3M
EPS estimate$0.19

Next report

Nov 9, 2026 (in 2 months)
Revenue estimate$20.8M
EPS estimate-$0.42

Financials

Q3 2025

Income statement

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Revenue$21.5M+12,113%
Operating income$2.6M+112%
Net income$8.2M+140%
EPS (diluted)$0.18+102%

Balance sheet

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Cash & equivalents$320.0M+263%
Total debt$24.1M-4.4%
Total equity$388.7M+545%
Total assets$606.7M+248%

Cash flow

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Operating cash flow$168.8M+1,104%
CapEx$13.0K-97.8%
Free cash flow$168.8M+1,071%

Valuation & ratios

Valuation

as of 09/30/25
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Market cap$838.65M—
Enterprise value$542.77M—
P/S38×—

Profitability

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Operating margin-349.2%-160pp
Net margin-266.8%-122pp
FCF margin467.9%+243pp

Returns & leverage

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Debt / equity0.1×—
Current ratio6.5×-3.6×

FAQ

When did Septerna, Inc. report Q3 2025 earnings?
Septerna, Inc. (SEPN) reported Q3 2025 earnings on November 10, 2025 before market open.
What were Septerna, Inc.'s Q3 2025 revenue and EPS?
Septerna, Inc. reported revenue of $21.5M and eps of $-0.09 for Q3 2025.
Did Septerna, Inc. beat estimates in Q3 2025?
Revenue beat the consensus estimate of $17.3M by $4.2M. EPS missed the consensus estimate of $0.19 by $0.28.
How did Septerna, Inc.'s Q3 2025 results compare year-over-year?
Compared to the same quarter a year prior, revenue grew 12113.1% from $176.0K a year earlier and eps grew 98.9% from $-8.40.
Where can I find Septerna, Inc.'s Q3 2025 SEC filings?
You can read the 8-K earnings release (0001193125-25-273373) and the 10-Q periodic report (0001193125-25-273375) directly on SEC EDGAR. The filing index links above go to sec.gov.