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Septerna, Inc. SEPN Q3 2025 earnings

Reported November 10, 2025 · Before market open

Revenue$21.5MBeat by $4.2MDiluted EPS-$0.09Miss by $0.28
Revenue estimate$17.3M
EPS estimate$0.19

Next report

Aug 10, 2026 (In 4 weeks)
Revenue estimate$19.2M
EPS estimate-$0.48

Financials

Q3 2025

Income statement

See full
Revenue$21.5M+12,113%
Operating income$2.6M+112%
Net income$8.2M+140%
EPS (diluted)$0.18+102%

Balance sheet

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Cash & equivalents$320.0M+263%
Total debt$24.1M-4.4%
Total equity$388.7M+545%
Total assets$606.7M+248%

Cash flow

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Operating cash flow$168.8M+1,104%
CapEx$13.0K-97.8%
Free cash flow$168.8M+1,071%

Valuation & ratios

Valuation

as of 09/30/25
See full
Market cap$838.65M—
Enterprise value$542.77M—
P/S38×—

Profitability

See full
Operating margin-349.2%-160pp
Net margin-266.8%-122pp
FCF margin467.9%+243pp

Returns & leverage

See full
Debt / equity0.1×—
Current ratio6.5×-3.6×

Versus estimates

Revenue

Q1 2026$26.5MBeat by $9.5MQ4 2025$24.1MBeat by $5.9M
Q3 2025$21.5MBeat by $4.2M
Q2 2025$119.0KMiss by $4.9MQ1 2025$219.0KMiss by $29.8MQ4 2024$212.0K

Diluted EPS

Q1 2026-$0.19Beat by $0.32Q4 2025-$0.24Miss by $0.01
Q3 2025-$0.09Miss by $0.28
Q2 2025-$0.56Miss by $0.51Q1 2025-$0.49Miss by $0.11Q4 2024-$0.64Beat by $0.05

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Questions, answered.

When did Septerna, Inc. report Q3 2025 earnings?
Septerna, Inc. (SEPN) reported Q3 2025 earnings on November 10, 2025 before market open.
What were Septerna, Inc.'s Q3 2025 revenue and EPS?
Septerna, Inc. reported revenue of $21.5M and diluted EPS of $-0.09 for Q3 2025.
Did Septerna, Inc. beat estimates in Q3 2025?
Revenue beat the consensus estimate of $17.3M by $4.2M. EPS missed the consensus estimate of $0.19 by $0.28.
How did Septerna, Inc.'s Q3 2025 results compare year-over-year?
Compared to the same quarter a year prior, revenue grew 12113.1% from $176.0K a year earlier and diluted EPS grew 98.9% from $-8.40.
Where can I find Septerna, Inc.'s Q3 2025 SEC filings?
You can read the 8-K earnings release (0001193125-25-273373) and the 10-Q periodic report (0001193125-25-273375) directly on SEC EDGAR. The filing index links above go to sec.gov.