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Septerna, Inc. SEPN Q4 2025 Annual earnings

Reported March 9, 2026 · Before market open

Revenue$24.1MBeat by $5.9M
EPS-$0.24Miss by $0.01
Revenue estimate$18.2M
EPS estimate-$0.23

Next report

Nov 9, 2026 (in 2 months)
Revenue estimate$20.8M
EPS estimate-$0.42

Financials

Q4 2025

Income statement

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Revenue$24.1M+11,276%
Operating income-$16.0M+35.2%
Net income-$10.7M+48.0%
EPS (diluted)-$0.24—

Balance sheet

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Cash & equivalents$120.7M-49.3%
Total debt$23.6M-7.3%
Total equity$381.9M-9.1%
Total assets$596.2M+30.6%

Cash flow

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CapEx$65.0K-89.4%

Valuation & ratios

Valuation

as of 12/31/25
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Market cap$1.25B+22.8%
Enterprise value$1.15B+43.2%
P/S27.2×-919×

Profitability

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Operating margin-148.6%-73.6pp
Net margin-106.4%-52.8pp

Returns & leverage

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Return on equity-12.2%—
Debt / equity0.1×0.0×
Current ratio4.7×-23.0×

FAQ

When did Septerna, Inc. report Q4 2025 earnings?
Septerna, Inc. (SEPN) reported Q4 2025 earnings on March 9, 2026 before market open.
What were Septerna, Inc.'s Q4 2025 revenue and EPS?
Septerna, Inc. reported revenue of $24.1M and eps of $-0.24 for Q4 2025.
Did Septerna, Inc. beat estimates in Q4 2025?
Revenue beat the consensus estimate of $18.2M by $5.9M. EPS missed the consensus estimate of $-0.23 by $0.01.
How did Septerna, Inc.'s Q4 2025 results compare year-over-year?
Compared to the same quarter a year prior, revenue grew 11276.4% from $212.0K a year earlier and eps grew 62.5% from $-0.64.
Where can I find Septerna, Inc.'s Q4 2025 SEC filings?
You can read the 8-K earnings release (0001193125-26-098489) and the 10-K periodic report (0001193125-26-098507) directly on SEC EDGAR. The filing index links above go to sec.gov.