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Septerna, Inc. SEPN Material Right — Non Refundable One Time Upfront Payment Received

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Other financials

Income statement

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Revenue$26.7M+22,376%
Operating income-$16.8M+41.9%
Net income-$13.0M+47.5%
EPS (diluted)-$0.29+48.2%

Balance sheet

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Cash & equivalents$84.7M-55.3%
Total debt$22.5M-8.2%
Total equity$386.7M+2.4%
Total assets$566.7M+36.5%

Cash flow

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Operating cash flow-$22.2M-9.3%
CapEx$832.0K+118%
Free cash flow-$22.2M-9.0%

Valuation

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Market cap$1.78B+240%
Enterprise value$1.72B+379%
P/S18×-703×

Profitability

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Operating margin-44%-22.0pp
Net margin-24.5%-12.2pp
FCF margin467.9%+243pp

Returns & leverage

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Return on equity-6.3%
Debt / equity0.1×0.0×
Current ratio-17.1×

Where this comes from

Reported directly by Septerna, Inc. in its filing.

Tagged under the XBRL concept sepn:NonRefundableOneTimeUpfrontPaymentReceived.

The source filing: Septerna, Inc.’s 10-Q, filed May 11, 2026.

Filed
May 11, 2026, 4:08 PM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001193125-26-216759

Comprised of the allocation of the $195.0 million one-time, non-refundable upfront payment, of which $153.8 million was allocated to the four R&D programs and manufacturing services and $41.2 million was allocated to the material right. In addition, $94.0 million of variable consideration related to estimated research and manufacturing services for the four R&D Programs, and $2.0 million of variable consideration related to the two milestones deemed probable of achievement was allocated to the transaction price as of March 31, 2026.

Item 1. Condensed Financial Statements.

FAQ

What is Septerna, Inc.'s material right — non refundable one time upfront payment received?
Septerna, Inc. (SEPN) reported material right — non refundable one time upfront payment received of $41.2M in Q1 2026.
How has Septerna, Inc.'s material right — non refundable one time upfront payment received changed year-over-year?
Septerna, Inc.'s material right — non refundable one time upfront payment received increased by 300.0% year-over-year, from $10.3M to $41.2M.
What does material right — non refundable one time upfront payment received mean?
This metric tracks the initial cash consideration received upon the execution of a contract that is not subject to refund, regardless of future performance outcomes. It provides immediate liquidity and serves as a key indicator of the initial commercial validation of a company's technology or drug pipeline. Monitoring this inflow helps investors assess the company's ability to monetize its intellectual property early in the partnership lifecycle.

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