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Upstream Bio, Inc. UPB Q4 2025 Annual earnings

Reported March 26, 2026 · Before market open

Revenue$668.0KBeat by $84.0K
EPS-$0.79Miss by $0.06
Revenue estimate$584.0K
EPS estimate-$0.73

Next report

Nov 4, 2026 (in 2 months)
Revenue estimate$522.5K
EPS estimate-$0.73

Financials

Q4 2025

Income statement

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Revenue$668.0K+9.0%
Operating income-$46.2M-75.4%
Net income-$42.5M-99.9%
EPS (diluted)-$0.78—

Balance sheet

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Cash & equivalents$101.6M-68.8%
Total debt$1.3M-30.8%
Total equity$339.8M-27.7%
Total assets$353.8M-26.6%

Cash flow

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Operating cash flow-$30.6M-56.2%
CapEx$54.0K-70.8%
Free cash flow-$30.7M-55.0%

Valuation & ratios

Valuation

as of 12/31/25
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Market cap$1.47B+66.5%
Enterprise value$1.37B+145%
P/S514.1×+142×

Profitability

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Operating margin-5,618.8%+13,921pp
Net margin-5,026%+43,575pp

Returns & leverage

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Return on equity-35.4%—
Debt / equity0×0.0×
Current ratio26.2×-18.5×

FAQ

When did Upstream Bio, Inc. report Q4 2025 earnings?
Upstream Bio, Inc. (UPB) reported Q4 2025 earnings on March 26, 2026 before market open.
What were Upstream Bio, Inc.'s Q4 2025 revenue and EPS?
Upstream Bio, Inc. reported revenue of $668.0K and eps of $-0.79 for Q4 2025.
Did Upstream Bio, Inc. beat estimates in Q4 2025?
Revenue beat the consensus estimate of $584.0K by $84.0K. EPS missed the consensus estimate of $-0.73 by $0.06.
How did Upstream Bio, Inc.'s Q4 2025 results compare year-over-year?
Compared to the same quarter a year prior, revenue grew 9.0% from $613.0K a year earlier and eps grew 50.3% from $-1.59.
Where can I find Upstream Bio, Inc.'s Q4 2025 SEC filings?
You can read the 8-K earnings release (0001193125-26-125057) and the 10-K periodic report (0001193125-26-126188) directly on SEC EDGAR. The filing index links above go to sec.gov.