Skip to content
OpenCapital
Get started

Upstream Bio, Inc. UPB Q4 2025 Annual earnings

Reported March 26, 2026 · Before market open

Revenue$668.0KBeat by $84.0KDiluted EPS-$0.79Miss by $0.06
Revenue estimate$584.0K
EPS estimate-$0.73

Next report

Aug 5, 2026 (In 3 weeks)
Revenue estimate$431.1K
EPS estimate-$0.78

Financials

Q4 2025

Income statement

See full
Revenue$668.0K+9.0%
Operating income-$46.2M-75.4%
Net income-$42.5M-99.9%
EPS (diluted)-$0.78—

Balance sheet

See full
Cash & equivalents$101.6M-68.8%
Total debt$1.3M-30.8%
Total equity$339.8M-27.7%
Total assets$353.8M-26.6%

Cash flow

See full
Operating cash flow-$30.6M-56.2%
CapEx$54.0K-70.8%
Free cash flow-$30.7M-55.0%

Valuation & ratios

Valuation

as of 12/31/25
See full
Market cap$1.47B+66.5%
Enterprise value$1.37B+145%
P/S514.1×+142×

Profitability

See full
Operating margin-5,618.8%+13,921pp
Net margin-5,026%+43,575pp

Returns & leverage

See full
Return on equity-35.4%—
Debt / equity0×0.0×
Current ratio26.2×-18.5×

Versus estimates

Revenue

Q1 2026$1.0MBeat by $6.3K
Q4 2025$668.0KBeat by $84.0K
Q3 2025$683.0KBeat by $161.4KQ2 2025$937.0KBeat by $620.0KQ1 2025$566.0KBeat by $249.0KQ4 2024$613.0KBeat by $286.8K

Diluted EPS

Q1 2026-$0.75Miss by $0.01
Q4 2025-$0.79Miss by $0.06
Q3 2025-$0.63Beat by $0.15Q2 2025-$0.74Miss by $0.13Q1 2025-$0.51Miss by $0.02Q4 2024-$1.59Miss by $1.03

Ask the moment Upstream Bio, Inc. reports.

Connect your AI and ask the moment the filing drops. It reads the release, surfaces what management said, and gives you its own read.

Connect your AI
Harbor at dusk
Claude

Questions, answered.

When did Upstream Bio, Inc. report Q4 2025 earnings?
Upstream Bio, Inc. (UPB) reported Q4 2025 earnings on March 26, 2026 before market open.
What were Upstream Bio, Inc.'s Q4 2025 revenue and EPS?
Upstream Bio, Inc. reported revenue of $668.0K and diluted EPS of $-0.79 for Q4 2025.
Did Upstream Bio, Inc. beat estimates in Q4 2025?
Revenue beat the consensus estimate of $584.0K by $84.0K. EPS missed the consensus estimate of $-0.73 by $0.06.
How did Upstream Bio, Inc.'s Q4 2025 results compare year-over-year?
Compared to the same quarter a year prior, revenue grew 9.0% from $613.0K a year earlier and diluted EPS grew 50.3% from $-1.59.
Where can I find Upstream Bio, Inc.'s Q4 2025 SEC filings?
You can read the 8-K earnings release (0001193125-26-125057) and the 10-K periodic report (0001193125-26-126188) directly on SEC EDGAR. The filing index links above go to sec.gov.