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EBITDA margin at other companies

Amgen logo
AmgenAMGN
42.2%+3.0pp
Regeneron Pharmaceuticals logo
Regeneron PharmaceuticalsREGN
28.1%-2.5pp
Aclaris Therapeutics logo
Aclaris TherapeuticsACRS
-1,045%+263pp
Shattuck Labs, Inc. logo
Shattuck Labs, Inc.STTK
-5,222.2%-14,609pp
AnaptysBio, Inc. logo
AnaptysBio, Inc.ANAB
17.8%+9.7pp
Avalo Therapeutics logo
Avalo TherapeuticsAVTX
-15,497.7%-17,225pp

Other financials

Income statement

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Revenue$773.0K-17.5%
Operating income-$42.4M+4.5%
Net income-$39.7M+0.7%
EPS (diluted)-$0.73+1.4%

Balance sheet

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Cash & equivalents$79.4M+74.7%
Total debt$954.0K-38.9%
Total equity$271.0M-33.7%
Total assets$281.2M-33.1%

Cash flow

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Operating cash flow-$35.6M+9.2%
CapEx$54.0K-70.8%
Free cash flow-$30.7M-55.0%

Valuation

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Market cap$394.54M-54.7%
Enterprise value$316.1M-61.6%
P/S124.9×-195×

Profitability

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Operating margin-5,382.6%+1,393pp
Net margin-4,955.7%+2,041pp

Returns & leverage

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Return on equity-46%
Debt / equity0.0×
Current ratio28×-10.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

Based on trailing twelve months.

The source filing: Upstream Bio, Inc.’s 10-Q, filed August 11, 2026. Open the filing →

Filed
Aug 11, 2026, 7:10 AM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0001193125-26-343417

FAQ

What is Upstream Bio, Inc.'s EBITDA margin?
Upstream Bio, Inc. (UPB) reported EBITDA margin of -5,376.3% in Q2 2026.
How has Upstream Bio, Inc.'s EBITDA margin changed year-over-year?
Upstream Bio, Inc.'s EBITDA margin decreased by 20.6% year-over-year, from -4,459.2% to -5,376.3%.
What does EBITDA margin mean?
EBITDA (earnings before interest, taxes, depreciation, and amortization) as a percentage of revenue, trailing twelve months. A proxy for cash operating profitability that strips out capital-structure and non-cash charges.

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