What is Upstream Bio, Inc.'s EBITDA margin?

Upstream Bio, Inc. (UPB) reported EBITDA margin of -5,170.7% in Q1 2026.

How has Upstream Bio, Inc.'s EBITDA margin changed year-over-year?

Upstream Bio, Inc.'s EBITDA margin decreased by 25.4% year-over-year, from -4,122.2% to -5,170.7%.

What does EBITDA margin mean?

EBITDA (earnings before interest, taxes, depreciation, and amortization) as a percentage of revenue, trailing twelve months. A proxy for cash operating profitability that strips out capital-structure and non-cash charges.

Upstream Bio, Inc. UPB EBITDA margin

EBITDA margin at other companies

AmgenAMGN

41.5%+3.4pp

Regeneron PharmaceuticalsREGN

27.9%-2.8pp

Aclaris TherapeuticsACRS

-956.8%+257pp

Shattuck Labs, Inc.STTK

-4,902.1%-9,075pp

AnaptysBio, Inc.ANAB

17.8%+9.7pp

Avalo TherapeuticsAVTX

-15,497.7%-17,225pp

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

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Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

ebitda/total revenue=-5,170.7%

Based on trailing twelve months.

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s EBITDA margin?: Upstream Bio, Inc. (UPB) reported EBITDA margin of -5,170.7% in Q1 2026.
How has Upstream Bio, Inc.'s EBITDA margin changed year-over-year?: Upstream Bio, Inc.'s EBITDA margin decreased by 25.4% year-over-year, from -4,122.2% to -5,170.7%.
What does EBITDA margin mean?: EBITDA (earnings before interest, taxes, depreciation, and amortization) as a percentage of revenue, trailing twelve months. A proxy for cash operating profitability that strips out capital-structure and non-cash charges.