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Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$9.12B+846%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:CommonStockSharesAuthorized.

The source filing: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026.

Filed
May 5, 2026, 8:00 AM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001636282-26-000050
Line itemMarch 31,2026December 31,2025
Series A non-voting convertible preferred stock, $0.0001 par value; 1,086,341 shares authorized as of March 31, 2026 and December 31, 2025; 346,045 shares issued and outstanding as of March 31, 2026 and December 31, 2025.146,425146,425
Series B non-voting convertible preferred stock, $0.0001 par value; 271,625 shares authorized and 16,667 shares issued and outstanding as of March 31, 2026 and December 31, 2025.9,3959,395
Preferred stock, $0.0001 par value; 8,642,034 shares authorized as of March 31, 2026 and December 31, 2025; no shares issued and outstanding as of March 31, 2026 and December 31, 2025.
Common stock, $0.0001 par value; 400,000,000 shares authorized as of March 31, 2026 and December 31, 2025; 78,839,858 shares and 78,189,811 shares issued and outstanding as of March 31, 2026 and December 31, 2025, respectively.1515
Additional paid-in capital1,712,3831,686,167
Accumulated other comprehensive (loss) income(767)869
Accumulated deficit(1,196,640)(1,127,635)
TOTAL STOCKHOLDERS’ EQUITY670,811715,236

Item 1. Financial Statements (Unaudited).

FAQ

What is Spyre Therapeutics, Inc.'s common stock?
Spyre Therapeutics, Inc. (SYRE) reported common stock of 400M in Q1 2026.
How has Spyre Therapeutics, Inc.'s common stock changed year-over-year?
Spyre Therapeutics, Inc.'s common stock decreased by 0.0% year-over-year, from 400M to 400M.
What is the long-term trend for Spyre Therapeutics, Inc.'s common stock?
Over 5 years (2020 to 2025), Spyre Therapeutics, Inc.'s common stock has grown at a 856.4% compound annual growth rate (CAGR), from 5K to 400M.
What does common stock mean?
The par value of all common shares issued and outstanding, typically a nominal amount ($0.01 or $0.001 per share).

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