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EBITDA at other companies

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Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$9.12B+846%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Calculated from Spyre Therapeutics, Inc.’s reported figures.

$57.2Mebit+
-Depreciation Depletion & Amortization
=-$57.17M

The source filing: Spyre Therapeutics, Inc.’s 10-K, filed February 19, 2026. Open the filing →

Filed
Feb 19, 2026, 4:01 PM EST
Fiscal year
FY2025
Accession
0001636282-26-000020

FAQ

What is Spyre Therapeutics, Inc.'s EBITDA?
Spyre Therapeutics, Inc. (SYRE) reported EBITDA of -$57.17M in Q4 2025.
How has Spyre Therapeutics, Inc.'s EBITDA changed year-over-year?
Spyre Therapeutics, Inc.'s EBITDA increased by 6.7% year-over-year, from -$61.25M to -$57.17M.
What is the long-term trend for Spyre Therapeutics, Inc.'s EBITDA?
Over 3 years (2021 to 2025), Spyre Therapeutics, Inc.'s EBITDA has grown at a 48.4% compound annual growth rate (CAGR), from -$64.07M to -$209.56M.
What does EBITDA mean?
Earnings before interest, taxes, depreciation, and amortization — EBIT plus the D&A add-back from the cash-flow statement (EBITDA = EBIT + D&A). A proxy for cash earnings that strips out financing, tax, and non-cash charges.

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