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Spyre Therapeutics, Inc. SYRE Short-Term Investments

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Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$9.12B+846%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:AvailableForSaleSecuritiesDebtSecuritiesCurrent.

The source filing: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026.

Filed
May 5, 2026, 8:00 AM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001636282-26-000050
Line itemMarch 31,2026December 31,2025
ASSETS
CURRENT ASSETS
Cash and cash equivalents$97,185$85,721
Marketable securities644,282670,812
Prepaid expenses and other current assets22,48621,248
Total current assets763,953777,781
TOTAL ASSETS$763,953$777,781
LIABILITIES AND STOCKHOLDERS’ EQUITY

Item 1. Financial Statements (Unaudited).

FAQ

What is Spyre Therapeutics, Inc.'s short-term investments?
Spyre Therapeutics, Inc. (SYRE) reported short-term investments of $644.28M in Q1 2026.
How has Spyre Therapeutics, Inc.'s short-term investments changed year-over-year?
Spyre Therapeutics, Inc.'s short-term investments increased by 24.8% year-over-year, from $516.33M to $644.28M.
What is the long-term trend for Spyre Therapeutics, Inc.'s short-term investments?
Over 5 years (2020 to 2025), Spyre Therapeutics, Inc.'s short-term investments has grown at a 64.2% compound annual growth rate (CAGR), from $56.18M to $670.81M.
What does short-term investments mean?
Marketable securities and other investments with maturities between three months and one year, providing yield above cash while maintaining liquidity.

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