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Spyre Therapeutics, Inc. SYRE Business Segments — Other segment items

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Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$9.12B+846%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:SegmentReportingOtherItemAmount.

The source filing: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026.

Filed
May 5, 2026, 8:00 AM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001636282-26-000050
Line itemThree Months Ended March 31, 20262025
Compensation$11,443$6,991
Stock-based compensation (1)12,8068,859
Research and development, excluding compensation and stock-based compensation (2) (3)46,89333,551
Other segment items (4) (5)(2,137)(4,628)
Segment net loss$69,005$44,773

Item 1. Financial Statements (Unaudited).

FAQ

What is Spyre Therapeutics, Inc.'s business segments — other segment items?
Spyre Therapeutics, Inc. (SYRE) reported business segments — other segment items of -$2.14M in Q1 2026.
How has Spyre Therapeutics, Inc.'s business segments — other segment items changed year-over-year?
Spyre Therapeutics, Inc.'s business segments — other segment items increased by 53.8% year-over-year, from -$4.63M to -$2.14M.
What is the long-term trend for Spyre Therapeutics, Inc.'s business segments — other segment items?
Over 2 years (2022 to 2024), Spyre Therapeutics, Inc.'s business segments — other segment items has grown at a 10.2% compound annual growth rate (CAGR), from $12.56M to $15.26M.
What does business segments — other segment items mean?
Residual operational income or expenses within the segment that do not fall into standard categories like R&D or compensation. This often includes one-time charges, gains on asset sales, or miscellaneous overhead allocations.

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