What is Septerna, Inc.'s free cash flow yield?

Septerna, Inc. (SEPN) reported free cash flow yield of 12.3% in Q3 2025.

What does free cash flow yield mean?

Trailing-twelve-month free cash flow divided by market capitalization at the quarter end. The cash return the business generates relative to its market price.

Septerna, Inc. SEPN Free cash flow yield

Free cash flow yield at other companies

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22.9%+19.6pp

Other financials

Income statement

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Revenue$26.5M+12,011%

Operating income-$13.3M+48.7%

Net income-$8.6M+59.8%

EPS (diluted)-$0.19+61.2%

Balance sheet

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Cash & equivalents$71.6M-65.9%

Total debt$23.1M-7.7%

Total equity$378.5M+195%

Total assets$569.7M+31.3%

Cash flow

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Operating cash flow-$25.6M-9.8%

CapEx$832.0K+118%

Free cash flow-$26.5M-11.5%

Valuation

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Market cap$1.62B+319%

Enterprise value$1.58B+1,325%

P/S22.5×-374×

Profitability

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Operating margin-77.1%-38.4pp

Net margin-49.9%-24.9pp

FCF margin467.9%+243pp

Returns & leverage

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Return on equity-12.2%—

Debt / equity0.1×—

Current ratio4.7×-27.5×

Where this comes from

Calculated from Septerna, Inc.’s reported figures.

free cash flow/market cap=12.3%

Based on trailing twelve months.

The official record: Septerna, Inc.’s 10-Q, filed November 10, 2025, on SEC EDGAR. View the filing →

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Questions, answered.

What is Septerna, Inc.'s free cash flow yield?: Septerna, Inc. (SEPN) reported free cash flow yield of 12.3% in Q3 2025.
What does free cash flow yield mean?: Trailing-twelve-month free cash flow divided by market capitalization at the quarter end. The cash return the business generates relative to its market price.