What is Upstream Bio, Inc.'s AOCI?

Upstream Bio, Inc. (UPB) reported AOCI of $100K in Q1 2026.

How has Upstream Bio, Inc.'s AOCI changed year-over-year?

Upstream Bio, Inc.'s AOCI decreased by 72.8% year-over-year, from $368K to $100K.

What is the long-term trend for Upstream Bio, Inc.'s AOCI?

Over 2 years (2023 to 2025), Upstream Bio, Inc.'s AOCI has grown at a 402.4% compound annual growth rate (CAGR), from $21K to $530K.

Accumulated gains and losses bypassing the income statement — unrealized investment gains/losses, currency translation, pension adjustments, and hedge results.

Upstream Bio, Inc. UPB AOCI

AOCI at other companies

AmgenAMGN

-$190M+17.7%

Regeneron PharmaceuticalsREGN

$11.9M-59.1%

Aclaris TherapeuticsACRS

$22K-94.9%

Shattuck Labs, Inc.STTK

$0—

SavaraSVRA

-$429K+32.1%

AnaptysBio, Inc.ANAB

-$146K-191%

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

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Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Reported directly by Upstream Bio, Inc. in its filing.

Tagged under the XBRL concept us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax.

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s AOCI?: Upstream Bio, Inc. (UPB) reported AOCI of $100K in Q1 2026.
How has Upstream Bio, Inc.'s AOCI changed year-over-year?: Upstream Bio, Inc.'s AOCI decreased by 72.8% year-over-year, from $368K to $100K.
What is the long-term trend for Upstream Bio, Inc.'s AOCI?: Over 2 years (2023 to 2025), Upstream Bio, Inc.'s AOCI has grown at a 402.4% compound annual growth rate (CAGR), from $21K to $530K.
What does AOCI mean?: Accumulated gains and losses bypassing the income statement — unrealized investment gains/losses, currency translation, pension adjustments, and hedge results.