What is Upstream Bio, Inc.'s EV / sales?

Upstream Bio, Inc. (UPB) reported EV / sales of 118.7× in Q1 2026.

How has Upstream Bio, Inc.'s EV / sales changed year-over-year?

Upstream Bio, Inc.'s EV / sales increased by 5.3% year-over-year, from 112.7× to 118.7×.

What does EV / sales mean?

Enterprise value at the quarter end divided by trailing-twelve-month revenue. A capital-structure-neutral revenue multiple, useful when earnings are negative.

Upstream Bio, Inc. UPB EV / sales

EV / sales at other companies

AmgenAMGN

6.6×+0.1×

Regeneron PharmaceuticalsREGN

5.5×+0.6×

Aclaris TherapeuticsACRS

51.1×+43.3×

Shattuck Labs, Inc.STTK

372.6×+370×

AnaptysBio, Inc.ANAB

5.8×+1.4×

Avalo TherapeuticsAVTX

-127.1×-128×

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

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Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

enterprise value/total revenue=118.7×

Based on the most recent quarter.

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s EV / sales?: Upstream Bio, Inc. (UPB) reported EV / sales of 118.7× in Q1 2026.
How has Upstream Bio, Inc.'s EV / sales changed year-over-year?: Upstream Bio, Inc.'s EV / sales increased by 5.3% year-over-year, from 112.7× to 118.7×.
What does EV / sales mean?: Enterprise value at the quarter end divided by trailing-twelve-month revenue. A capital-structure-neutral revenue multiple, useful when earnings are negative.