What is Upstream Bio, Inc.'s return on assets?

Upstream Bio, Inc. (UPB) reported return on assets of -40.5% in Q1 2026.

What does return on assets mean?

Trailing-twelve-month net income divided by average total assets. Measures how efficiently the asset base generates profit, independent of how those assets are financed. Computed as net income over average total assets — note this is OpenCapital's standard definition and may differ from data vendors that use alternative numerators.

Upstream Bio, Inc. UPB Return on assets

Name: Upstream Bio, Inc. Return on assets — Quarterly & Annual Data
Creator: OpenCapital
License: https://www.opencapital.sh/terms

Return on assets at other companies

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8.6%+2.1pp

Regeneron PharmaceuticalsREGN

11.3%-1.2pp

Aclaris TherapeuticsACRS

-35.1%-11.7pp

Shattuck Labs, Inc.STTK

-55.6%-5.9pp

SavaraSVRA

-63%+4.9pp

AnaptysBio, Inc.ANAB

-20%-5.8pp

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

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Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

net income/total assets=-40.5%

Based on trailing twelve months.

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s return on assets?: Upstream Bio, Inc. (UPB) reported return on assets of -40.5% in Q1 2026.
What does return on assets mean?: Trailing-twelve-month net income divided by average total assets. Measures how efficiently the asset base generates profit, independent of how those assets are financed. Computed as net income over average total assets — note this is OpenCapital's standard definition and may differ from data vendors that use alternative numerators.