What does acquired in-process research and development mean?

This metric represents the value assigned to research and development projects acquired through business combinations that have not yet reached technological feasibility. These costs are expensed as incurred because the acquired assets have no alternative future use. It reflects the strategic investment in external innovation pipelines.

Spyre Therapeutics, Inc. SYRE Acquired in-process research and development

Discontinued — last reported Q4 '25

Acquired in-process research and development at other companies

Eli LillyLLY

$584M-62.8%

Gilead SciencesGILD

$107M-57.7%

Circle Internet Group, Inc.CRCL

$0—

Gen Digital Inc.GEN

$10M—

Regeneron PharmaceuticalsREGN

$101.9M+728%

AccentureACN

$204.33M-29.0%

Other financials

Income statement

See full

Revenue-—

Operating income-$45.6M+14.8%

Net income-$69.0M-54.1%

EPS (diluted)-$0.74-23.3%

Balance sheet

See full

Cash & equivalents$97.2M+100%

Total debt$4.3M-9.6%

Total equity$670.8M+39.0%

Total assets$764.0M+34.1%

Cash flow

See full

Operating cash flow-$57.4M-40.0%

CapEx-—

Free cash flow-$39.4M-26.8%

Valuation

See full

Market cap$7.67B+307%

Profitability

See full

Operating margin-39,428.9%-49,795pp

Net margin-52,939.7%-61,871pp

FCF margin-3,442.8%-3,807pp

Returns & leverage

See full

Return on equity-31.1%-10.7pp

Debt / equity0.1×+0.1×

Current ratio9×+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept syre:AcquiredInProcessResearchAndDevelopment.

The official record: Spyre Therapeutics, Inc.’s 10-K, filed February 19, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s acquired in-process research and development?: Spyre Therapeutics, Inc. (SYRE) reported acquired in-process research and development of $0 in Q4 2025.
What does acquired in-process research and development mean?: This metric represents the value assigned to research and development projects acquired through business combinations that have not yet reached technological feasibility. These costs are expensed as incurred because the acquired assets have no alternative future use. It reflects the strategic investment in external innovation pipelines.