What is Spyre Therapeutics, Inc.'s total?

Spyre Therapeutics, Inc. (SYRE) reported total of $645.05M in Q1 2026.

How has Spyre Therapeutics, Inc.'s total changed year-over-year?

Spyre Therapeutics, Inc.'s total increased by 25.1% year-over-year, from $515.68M to $645.05M.

What is the long-term trend for Spyre Therapeutics, Inc.'s total?

Over 3 years (2022 to 2025), Spyre Therapeutics, Inc.'s total has grown at a 217.8% compound annual growth rate (CAGR), from $20.88M to $669.94M.

Spyre Therapeutics, Inc. SYRE Total

Total at other companies

Merck & Co.MRK

——

BridgeBio PharmaBBIO

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Ionis PharmaceuticalsIONS

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Regeneron PharmaceuticalsREGN

——

AmgenAMGN

——

BiogenBIIB

——

Other financials

Income statement

See full

Revenue-—

Operating income-$45.6M+14.8%

Net income-$69.0M-54.1%

EPS (diluted)-$0.74-23.3%

Balance sheet

See full

Cash & equivalents$97.2M+100%

Total debt$4.3M-9.6%

Total equity$670.8M+39.0%

Total assets$764.0M+34.1%

Cash flow

See full

Operating cash flow-$57.4M-40.0%

CapEx-—

Free cash flow-$39.4M-26.8%

Valuation

See full

Market cap$7.67B+307%

Profitability

See full

Operating margin-39,428.9%-49,795pp

Net margin-52,939.7%-61,871pp

FCF margin-3,442.8%-3,807pp

Returns & leverage

See full

Return on equity-31.1%-10.7pp

Debt / equity0.1×+0.1×

Current ratio9×+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis.

The official record: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s total?: Spyre Therapeutics, Inc. (SYRE) reported total of $645.05M in Q1 2026.
How has Spyre Therapeutics, Inc.'s total changed year-over-year?: Spyre Therapeutics, Inc.'s total increased by 25.1% year-over-year, from $515.68M to $645.05M.
What is the long-term trend for Spyre Therapeutics, Inc.'s total?: Over 3 years (2022 to 2025), Spyre Therapeutics, Inc.'s total has grown at a 217.8% compound annual growth rate (CAGR), from $20.88M to $669.94M.