Where do Upstream Bio, Inc.'s ratios come from?

Every ratio is computed from Upstream Bio, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Upstream Bio, Inc. UPB Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Profitability
Operating margin	-5,176.5%+442pp	-5,618.8%-599pp	-5,020.1%-555pp	-4,464.6%-337pp	-4,127.4%-846pp
Net margin	-4,719%+307pp	-5,026%-659pp	-4,366.8%-530pp	-3,836.6%-388pp	-3,448.7%-799pp
EBITDA margin	-5,170.7%+442pp	-5,612.2%-599pp	-5,013.6%-554pp	-4,459.2%-337pp	-4,122.2%-845pp
Returns
Return on equity	-41.8%-6.4pp	-35.4%—	——	——	——
Return on assets	-40.5%-6.2pp	-34.3%+4.8pp	-39.2%—	——	——
Return on invested capital	-58.9%+24.4pp	-83.2%—	——	——	——
Efficiency
Asset turnover	0×0.0×	0×0.0×	0×—	——	——
Liquidity
Current ratio	23.1×-3.0×	26.2×-6.5×	32.7×-5.6×	38.3×-9.2×	47.4×+2.8×
Quick ratio	23.1×-3.0×	26.2×-6.5×	32.7×-5.6×	38.3×-9.2×	47.4×+2.8×
Cash ratio	7.1×-0.5×	7.6×+1.5×	6.1×+1.9×	4.2×-3.3×	7.5×-22.9×
Leverage
Debt-to-equity	0×0.0×	0×0.0×	0×0.0×	0×0.0×	0×0.0×
Debt-to-assets	0×0.0×	0×0.0×	0×0.0×	0×0.0×	0×0.0×
Per Share
Book value per share	$5.60-11.3%	$6.31-10.1%	$7.02-7.7%	$7.60-8.5%	$8.31-75.8%
Valuation
Market capitalization	$346.11M-40.9%	$1.47B+44.7%	$1.01B+65.5%	$612.71M+86.6%	$328.28M-62.7%
Enterprise value	$250.5M-51.4%	$1.37B+44.9%	$943.29M+65.8%	$568.81M+120%	$258.67M-53.6%
Price / sales	104.2×-151×	514.1×+152×	362.3×+137×	225×+82.0×	143×-229×
Price / book	1.1×-0.2×	4.3×+1.6×	2.7×+1.2×	1.5×+0.8×	0.7×-1.1×
EV / sales	75.4×-149×	478.9×+142×	337×+128×	208.9×+96.2×	112.7×-122×
Earnings yield	-45.3%-31.8pp	-9.8%+2.3pp	-12.1%+5.0pp	-17.1%+7.1pp	-24.1%-17.0pp

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Where do Upstream Bio, Inc.'s ratios come from?: Every ratio is computed from Upstream Bio, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.