What is Spyre Therapeutics, Inc.'s gross unrealized gains?

Spyre Therapeutics, Inc. (SYRE) reported gross unrealized gains of $290K in Q1 2026.

How has Spyre Therapeutics, Inc.'s gross unrealized gains changed year-over-year?

Spyre Therapeutics, Inc.'s gross unrealized gains decreased by 64.1% year-over-year, from $807K to $290K.

What is the long-term trend for Spyre Therapeutics, Inc.'s gross unrealized gains?

Over 3 years (2022 to 2025), Spyre Therapeutics, Inc.'s gross unrealized gains has grown at a 690.0% compound annual growth rate (CAGR), from $2K to $986K.

Spyre Therapeutics, Inc. SYRE Gross Unrealized Gains

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Other financials

Income statement

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Revenue-—

Operating income-$45.6M+14.8%

Net income-$69.0M-54.1%

EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%

Total debt$4.3M-9.6%

Total equity$670.8M+39.0%

Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%

CapEx-—

Free cash flow-$39.4M-26.8%

Valuation

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Market cap$7.67B+307%

Profitability

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Operating margin-39,428.9%-49,795pp

Net margin-52,939.7%-61,871pp

FCF margin-3,442.8%-3,807pp

Returns & leverage

See full

Return on equity-31.1%-10.7pp

Debt / equity0.1×+0.1×

Current ratio9×+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax.

The official record: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s gross unrealized gains?: Spyre Therapeutics, Inc. (SYRE) reported gross unrealized gains of $290K in Q1 2026.
How has Spyre Therapeutics, Inc.'s gross unrealized gains changed year-over-year?: Spyre Therapeutics, Inc.'s gross unrealized gains decreased by 64.1% year-over-year, from $807K to $290K.
What is the long-term trend for Spyre Therapeutics, Inc.'s gross unrealized gains?: Over 3 years (2022 to 2025), Spyre Therapeutics, Inc.'s gross unrealized gains has grown at a 690.0% compound annual growth rate (CAGR), from $2K to $986K.